H2N2V1, Main, Exploration, bibRecord, 000253

Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Identifieur interne : 000253 ( Main/Exploration ); précédent : 000252; suivant : 000254

Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Auteurs : Noemie Courtin [France] ; Aurelien Fotso Fotso [France] ; Pierre Fautrad [France] ; Floriane Mas [France] ; Marie-Christine Alessi [France] ; Beatrice Riteau [France]

Source :

Antiviral Research [ 0166-3542 ] ; 2017.

RBID : Hal:hal-01755130

English descriptors

mix :
- Antiviral, Formyl peptide receptor 2, Influenza virus.

Abstract

Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation. Finally, our preclinical studies showed that FPR2 antagonists protected mice from lethal infections induced by influenza, both in a prophylactic and therapeutic manner. Thus, FPR2 antagonists might be explored for novel treatments against influenza.

Url:

https://hal-amu.archives-ouvertes.fr/hal-01755130

DOI: 10.1016/j.antiviral.2017.05.001

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Hal, to step Corpus: 000021
to stream Hal, to step Curation: 000021
to stream Hal, to step Checkpoint: 000062
to stream Main, to step Merge: 000253
to stream Main, to step Curation: 000253

Le document en format XML

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<author><name sortKey="Mas, Floriane" sort="Mas, Floriane" uniqKey="Mas F" first="Floriane" last="Mas">Floriane Mas</name>
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<country>France</country>
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<orgName type="university">Université d'Aix-Marseille</orgName>
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</author>
<author><name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">          <idno type="RNSR">197417835D</idno>
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<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
<author><name sortKey="Riteau, Beatrice" sort="Riteau, Beatrice" uniqKey="Riteau B" first="Beatrice" last="Riteau">Beatrice Riteau</name>
<affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-180118" status="OLD">          <idno type="RNSR">197417835D</idno>
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          <orgName type="acronym">INRA</orgName>
          <date type="start">1946-05-18</date>
          <date type="end">2019-12-31</date>
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          <idno type="ISNI">0000 0001 2176 4817</idno>
          <orgName>Aix Marseille Université</orgName>
          <orgName type="acronym">AMU</orgName>
          <date type="start">2012-01-01</date>
          <desc>            <address>              <addrLine>Aix-Marseille UniversitéJardins du Pharo58 Boulevard Charles Livon13284 Marseille cedex 7</addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.univ-amu.fr/</ref>
          </desc>
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</tutelle>
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          <orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
          <orgName type="acronym">INSERM</orgName>
          <desc>            <address>              <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
              <country key="FR"></country>
            </address>
            <ref type="url">http://www.inserm.fr</ref>
          </desc>
        </org>
</tutelle>
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</hal:affiliation>
<country>France</country>
<placeName><settlement type="city">Marseille</settlement>
<region type="region" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
<orgName type="university">Université d'Aix-Marseille</orgName>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.antiviral.2017.05.001</idno>
<series><title level="j">Antiviral Research</title>
<idno type="ISSN">0166-3542</idno>
<imprint><date type="datePub">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>Antiviral</term>
<term>Formyl peptide receptor 2</term>
<term>Influenza virus</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">              <p>Influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. The aim of the study was to evaluate the effect of FPR2 antagonists PBP10 and BOC2 on influenza virus replication. We determined that these molecules exhibit antiviral effects against influenza A (H1N1, H3N2, H6N2) and B viruses. FPR2 antagonists used in combination with oseltamivir showed additive antiviral effects. Mechanistically, the antiviral effect of PBP10 and BOC2 is mediated through early inhibition of virus-induced ERK activation. Finally, our preclinical studies showed that FPR2 antagonists protected mice from lethal infections induced by influenza, both in a prophylactic and therapeutic manner. Thus, FPR2 antagonists might be explored for novel treatments against influenza.</p>
            </div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
<orgName><li>Université d'Aix-Marseille</li>
</orgName>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Courtin, Noemie" sort="Courtin, Noemie" uniqKey="Courtin N" first="Noemie" last="Courtin">Noemie Courtin</name>
</region>
<name sortKey="Alessi, Marie Christine" sort="Alessi, Marie Christine" uniqKey="Alessi M" first="Marie-Christine" last="Alessi">Marie-Christine Alessi</name>
<name sortKey="Fautrad, Pierre" sort="Fautrad, Pierre" uniqKey="Fautrad P" first="Pierre" last="Fautrad">Pierre Fautrad</name>
<name sortKey="Fotso, Aurelien Fotso" sort="Fotso, Aurelien Fotso" uniqKey="Fotso A" first="Aurelien Fotso" last="Fotso">Aurelien Fotso Fotso</name>
<name sortKey="Mas, Floriane" sort="Mas, Floriane" uniqKey="Mas F" first="Floriane" last="Mas">Floriane Mas</name>
<name sortKey="Riteau, Beatrice" sort="Riteau, Beatrice" uniqKey="Riteau B" first="Beatrice" last="Riteau">Beatrice Riteau</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses
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Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

Antiviral activity of Formyl Peptide Receptor 2 antagonists against influenza viruses

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